Dysexecutive function in Alzheimer's Disease: A genetic and neuropsychologic

 
   Lead Investigator:    Jesse Mez
   Institution      :    Columbia University
   E-Mail           :    jbm2154@columbia.edu
   Proposal ID      :    116


   Publications:


1  Mez J, Cosentino S, Brickman A, Huey E, Manly J, Mayeux R
   Characterization of Dysexecutive Versus Amnestic Alzheimer's Disease Phenotypes in the National Alzheimer's Coordinating Center (NACC) Database
   2012   Abstract  Neurology   78(S)   , 

   PUBLISHED



2  Mez J, Cosentino S, Brickman AM, Huey ED, Manly JJ, Mayeux R
   Dysexecutive versus amnestic Alzheimer disease subgroups: analysis of demographic, genetic, and vascular factors
   Journal Article  Alzheimer Dis Assoc Disord,27:218-225,2013,PMC3748394

   PUBLISHED





   Proposal Description:
   -To demonstrate that executive dysfunction is a primary and early feature in a    subset of AD patients.                                                            -To evaluate whether there is an inverse association between APOE4 and            executive dysfunction in AD patients.                                                                                                                               While AD patients classically present with predominantly episodic memory          deficits, the presentation actually can be quite heterogeneous. The literature    and clinical experience suggest that a subset of patients present with deficits   in executive function out of proportion to memory deficits. On structural and     functional imaging, these patients tend to have more frontal atrophy and          hypoperfusion respectively than amnestic AD patients. The literature has          presented conflicting data on whether the APOE4 allele occurs at a different      rate in dysexecutive AD patients relative to amnestic AD patients. I am           planning to identify the AD patients in NACC that have the dysexecutive           phenotype.  Subsequently, using analysis of variance, I plan to evaluate          whether the APOE4 allele occurs at a different rate in this subset.